Suhendan Ekmekcioglu Selected Research

Dinoprostone (PGE2)

1/2023	Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion.
5/2016	Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression.

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Suhendan Ekmekcioglu Research Topics

Disease

45	Neoplasms (Cancer) 02/2024 - 02/2002
42	Melanoma (Melanoma, Malignant) 01/2023 - 02/2002
4	Inflammation (Inflammations) 02/2024 - 11/2011
4	Neoplasm Metastasis (Metastasis) 12/2020 - 02/2002
3	Breast Neoplasms (Breast Cancer) 02/2007 - 10/2002
2	Hypoxia (Hypoxemia) 10/2016 - 08/2014
2	Disease Progression 05/2016 - 05/2004
1	Colitis 01/2022
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022
1	Enterocolitis 01/2022
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2017
1	Wilms Tumor (Wilm's Tumor) 01/2017
1	Adenocarcinoma 10/2016
1	Carcinogenesis 05/2016
1	Hemorrhage 07/2014
1	Hypertension (High Blood Pressure) 07/2014
1	Circulating Neoplastic Cells 07/2014
1	Septic Shock (Toxic Shock Syndrome) 04/2014
1	Idiopathic Pulmonary Fibrosis 04/2014
1	Tuberous Sclerosis (Bourneville's Disease) 02/2014
1	Necrosis 04/2013
1	Chronic Renal Insufficiency 01/2013
1	Lung Neoplasms (Lung Cancer) 02/2011

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2002
11	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2021 - 01/2003
11	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 10/2002
9	CytokinesIBA 02/2024 - 05/2004
7	interleukin-24 (ST16)IBA 02/2011 - 02/2002
4	EnzymesIBA 01/2023 - 09/2008
4	Macrophage Migration-Inhibitory FactorsIBA 05/2022 - 11/2015
4	InterferonsIBA 01/2022 - 07/2008
4	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 10/2002
4	Interleukin-10 (Interleukin 10)IBA 02/2007 - 05/2004
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2023 - 08/2014
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 12/2006
3	Messenger RNA (mRNA)IBA 01/2021 - 11/2011
3	LigandsIBA 11/2015 - 12/2004
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2013 - 10/2002
3	InterleukinsIBA 11/2011 - 02/2007
2	Prostaglandin-E SynthasesIBA 01/2023 - 01/2019
2	Dinoprostone (PGE2)FDA Link 01/2023 - 05/2016
2	AntigensIBA 01/2021 - 01/2017
2	Small Interfering RNA (siRNA)IBA 01/2021 - 02/2014
2	Oncogene Proteins (Oncogene Protein)IBA 01/2021 - 01/2017
2	Phosphotransferases (Kinase)IBA 01/2021 - 08/2014
2	Arginine (L-Arginine)FDA Link 01/2018 - 01/2013
2	VemurafenibIBA 10/2016 - 10/2012
2	3-nitrotyrosineIBA 08/2014 - 09/2008
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2014 - 07/2014
2	Interleukin-1 (Interleukin 1)IBA 10/2012 - 11/2011
2	Cisplatin (Platino)FDA LinkGeneric 03/2010 - 03/2005
2	interleukin-20 receptorIBA 02/2007 - 12/2004
1	Interferon-gamma (Interferon, gamma)IBA 02/2024
1	Arachidonic Acid (Vitamin F)IBA 01/2023
1	CollagenIBA 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	CTLA-4 AntigenIBA 01/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2021
1	AntibodiesIBA 01/2021
1	Programmed Cell Death 1 ReceptorIBA 01/2021
1	3- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinoneIBA 02/2019
1	Dynamins (Dynamin)IBA 02/2019
1	OrnithineIBA 01/2018
1	CitrullineIBA 01/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2017
1	4- (benzo(b)thiophen- 2- yl)- 3- bromo- 5- hydroxydihydrofuran- 2(3H)- oneIBA 05/2016
1	Formaldehyde (Formol)FDA Link 08/2014
1	ParaffinIBA 08/2014
1	NitratesIBA 07/2014
1	OxidesIBA 07/2014
1	Bevacizumab (Avastin)FDA Link 07/2014
1	cediranib (AZD2171)IBA 07/2014
1	trans-sodium crocetinate (crocetin)IBA 02/2014
1	GTP Phosphohydrolases (GTPases)IBA 02/2014
1	DNA AdductsIBA 10/2013
1	Reactive Nitrogen SpeciesIBA 10/2013
1	Oxidants (Oxidizing Agents)IBA 10/2013
1	AntioxidantsIBA 10/2013
1	LipidsIBA 10/2013
1	Immunotoxins (Immunotoxin)IBA 04/2013
1	TWEAK ReceptorIBA 04/2013
1	Cell Surface ReceptorsIBA 04/2013
1	Indicators and Reagents (Reagents)IBA 04/2013
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2013
1	bardoxolone methylIBA 01/2013
1	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 01/2013
1	Interleukin-1alpha (Interleukin 1 alpha)IBA 10/2012
1	Neoplasm Antigens (Tumor Antigens)IBA 10/2012
1	ChemokinesIBA 08/2012
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 11/2011
1	Neutralizing AntibodiesIBA 11/2011
1	Caspase 9IBA 02/2011

Therapy/Procedure

18	Therapeutics 01/2023 - 02/2002
10	Immunotherapy 01/2023 - 11/2015
2	Drug Therapy (Chemotherapy) 03/2010 - 12/2008